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Therapeutic targeting of HGF/c-Met pathway. c-Met pathway inhibition... | Download Scientific Diagram

Glossary HTx hepatocyte transplantation OLT orthotopic liver transplantation ALF acute liver failure PHHs primary human hepatocyte HLC hepatocyte-like cells IBMIR instant blood-mediated inflammatory reaction BMP bone morphogenic protein DE definitive endoderm PFG posterior foregut HB hepatoblast FGFs fibroblast growth factors LSD1 lysine-specific demethylase 1 PSCs pluripotent stem cells hESCs human embryonic stem cells CHIR CHIR99021 AFP fetoprotein ALB albumin PROX1 prospero homeobox 1 NaB sodium butyrate DMSO dimethyl sulfoxide HGF hepatocyte growth factor HPCs hepatic progenitor cells FH1 functional hits 1 FPH1 functional proliferation hit 1 cGMP current good manufacturing practice hiPSC human iPSC MEFs mouse embryonic fibroblasts iHeps induced hepatocyte-like cells VPA valproic acid XEN extra-embryonic endoderm KMTs histone methyltransferases DNMTs DNA methyltransferases HDAC histone deacetylase KCs Kupffer cells HSCs hepatic stellate cells TF tissue factor MAC membrane attack complex GdCl3 Gadolinium chloride HIR hepatic irradiation References 1 Aguirre-VázquezA.Salazar-OlivoL

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Groups (n=12 per group): Sham (surgery + vehicle SC injection) BPC-157 monotherapy (10 μg/kg SC, daily) TB-500 monotherapy (1 mg/kg SC, daily) BPC-157 + TB-500 blend (10 μg/kg BPC + 1 mg/kg TB, daily, co-administered) Dosing schedule: Daily SC injection (dorsal neck) for 14 days post-surgery